| FACULTY
Department Head Residency Program Director Associate Head Professors |
Associate Professors Margaret Briehl, Ph.D.
Michael W. Riggs, Ph.D.
Catherine M. Spier, M.D.
Assistant Professors
Osama Abdelatif, M.D.
Jill Cohen, M.D.
Cynthia Porterfield, M.D.
Katherine M. Scott, M.D.
Margaret Tome, Ph.D.
Professors Emeritus
Douglas W. Huestis, M.D.
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Interim Department Head Dr. Bhattacharyya’s interests and expertise involve G.I. and liver pathology. He leads an active telepathology diagnostic practice in Arizona under the Arizona Telemedicine Program. As the Director of Surgical Pathology he is in the middle of a very busy clinical practice with a strong outreach program. Dr. Bhattacharyya is part of several American National Cancer Institute( NCI) research programs. These involve colon cancer prevention as well as G.I. cancer translational research. He actively collaborates with the Arizona Cancer Center, serves as the G.I. Pathologist for the center and leads a seminar every Wednesday for gastroenterologists. As of 2005, he has become part of the NCI think tank group for pancreatic cancer studies. He has published about 50 papers , made number of presentations including one at the IAP in Australia in 2004. He actively collaborates with pathologists in India and had presented his work on several occasions in the last 4 years. Along with the above-mentioned activities, Dr. Bhattacharyya maintains and balances an active teaching schedule for residents and second year medical students. He obtained several awards, including the award of “Basic Science Educator of the Year” for 2001 and 2002, “Dean’s List for Excellence in Teaching” 1999 and 2003, and the “John Davis Faculty of the Year” for 1999-2000. In summary, his professional activities include patient care, teaching and research.
Residency Program Director
Richard E. Sobonya, M.D. Following a fellowship in pulmonary pathology, Dr. Sobonya spent two years at the Armed Forces Institute of Pathology in the Pulmonary-Mediastinal Branch. He then joined the faculty at Kansas University Medical Center. He moved to the University of Arizona College of Medicine in 1977 and was a participating investigator in a multi- disciplinary NIH grant on the epidemiology of obstructive lung diseases. His special interests, besides lung pathology, include directing the Autopsy Service and participating in electron microscopy, muscle pathology, and cardiac pathology. He is the Director of the Residency Program and Secretary-Treasurer of PRODS (Program Directors Section of the Association of Pathology Chairs). Among his 70+ publications are articles on arrthymogenic right ventricular dysplasia and a chapter on fungal diseases in Churg's Pathology of the Lung. He is a Fellow of the American College of Chest Physicians and the College of American Pathologists. Extramedical interests include philately, lepidoptera, and fishing. Selected publications: Sobonya RE and Weinstein RS. Pathology manpower: a few rays of sunshine, Heme Pathol 32:669,2001.
Browne LW, Garland LL, Ebbinghaus SW, Grogan TM, Nagle RB, Rangel CS, Frutiger YM, Sobonya RE: Immunohistologic correlates of EGFR expression in non-small cell carcinoma by tissue microarray. Modern Path 15:316A, 2002. (abstract)
Co-Residency Program Director
Mary Berg, M.D. (MD, Medical College of Wisconsin) Dr. Mary Berg graduated from the Medical College of Wisconsin and did an internship in Internal Medicine at the Evanston Hospital, Evanston, IL. Her pathology residency was at Case Western Reserve University in Cleveland, followed by a fellowship in Blood Bank/Transfusion Medicine at the same institution. Before moving to Arizona, she was an Assistant Professor of Pathology at the University of Colorado Health Sciences Center. At Arizona she is Director of the Transfusion Medicine Service and Associate Director of the Pathology Residency Program for Clinical Pathology Training.
Selected publications: AN Bartley, D Redford, and M Berg: Transfusion Protocol for Implantation and Explantation of Cardiac Devices in an Academic Medical Center. ASAIO, 2007; 53: 320-323. MK Vaske and M Berg: Molecular Testing for RHD Genotyping, Transfusion Medicine Check Sample TM 06-4 (TM-288); 49 (4); 37-53, 2006. M Berg: Obstetric Hemorrhage. Lab Medicine, 2006; 37 (1): 45-9.J Gerdes, B Bertolani, and M Berg: Sharing out Best: Thawed Plasma, An Alternative to Fresh Frozen Plasma. J Trauma Nursing, 2005; Apr-Jun, 12 (2): 57-8. Associate Head
Naomi E. Rance, M.D., Ph.D. Dr. Naomi Rance received her Ph.D. in Physiology in the laboratory of Dr. Charles Barraclough at the University of Maryland Medical School. Her dissertation was in the field of Reproductive Neuroendocrinology. She subsequently entered the School of Medicine and received her M.D. degree in 1983. She completed a residency program in Pathology and fellowship training in Neuropathology at the Johns Hopkins Hospital in Baltimore. She is currently a Professor of Pathology and divides her time between clinical practice in Neuropathology and research in Neuroendocrinology. Dr. Rance has a longstanding interest in the effects of menopause on the human hypothalamus. The overall objective is to characterize and understand the events that occur in the human central nervous system in response to the ovarian failure of menopause. An equally important goal is to contribute to the understanding of the neuroendocrine mechanisms that regulate reproduction. Although complex, the neural basis of reproductive function is amenable to experimentation because of the known feedback circuits. Control mechanisms can be studied at many different levels, ranging from plasma hormones to gene expression in subsets of hypothalamic neurons. Dr. Rance has observed dramatic changes in the
hypothalamus of postmenopausal women. There is hypertrophy and increased gene expression of in a subpopulation of
hypothalamic neurons expressing estrogen receptor, neurokinin B and
substance P gene transcripts. In addition, in postmenopausal women, the gene expression of GnRH neurons
increases in a separate population of hypothalamic neurons. These changes appear to be due to ovarian failure because ovariectomy
of young monkeys results in both hypertrophy and increased gene expression
of neurokinin B neurons. The
hypertrophy of neurokinin B neurons occurs in association with gonadal
withdrawal and LH hypersecretion suggesting that these neurons participate
in the hypothalamic circuitry regulating estrogen negative feedback. Current studies in the laboratory are designed to test this
hypothesis. Selected publications: Escobar CM, Krajewski SJ, Sandoval-Guzmán T, Voytko ML, and Rance NE. 2004. Neuropeptide Y gene expression is increased in the infundibular nucleus of postmenopausal women. J Clin Endocrinol Metab 89:2338-2343. Sandoval-Guzmán T, Stalcup ST, Krajewski SJ, Voytko ML, and Rance NE. 2004. Characterization of the neuroendocrine axis regulating reproduction and body weight in intact and ovariectomized cynomolgus macaques. J Neuroendocrinol 16:146-153.
Krajewski SJ, Abel TW, Voytko ML, and Rance NE. 2003. Ovarian steroids differentially modulate the gene expression of GnRH neuronal subtypes in the ovariectomized cynomolgus monkey. J Clin Endocrinol Metab 88:655-662.
Abel TW and Rance NE. 2000. Stereologic study of the hypothalamic infundibular nucleus in young and older women. J Comp Neurol 424:679-688.
Danzer SC, McMullen NT, and Rance NE. 1998. Dendritic growth of arcuate neuroendocrine neurons following orchidectomy in adult rats. J Comp Neurol 390:234-246.
Rance NE and Uswandi SV. 1996. Gonadotropin-releasing hormone gene expression is increased in the medial basal hypothalamus of postmenopausal women. J Clin Endocrinol Metab 81:3540-3546.
Rance NE, Young WS, III, and McMullen NT. 1994. Topography of neurons expressing luteinizing hormone-releasing hormone gene transcripts in the human hypothalamus and basal forebrain. J Comp Neurol 339:573-586.
Rance NE and Young WS, III. 1991. Hypertrophy and increased gene expression of neurons containing neurokinin-B and substance-P messenger ribonucleic acids in the hypothalami of postmenopausal women. Endocrinology 128:2239-2247.
Rance
NE, McMullen NT, Smialek JE, Price DL, and Young WS, III. 1990.
Postmenopausal hypertrophy of neurons expressing the estrogen receptor
gene in the human hypothalamus. J Clin Endocrinol Metab 71:79-85. Professors
Chris Cunniff received his medical degree from the University of Alabama School of Medicine in 1984 and trained in Pediatrics at the University of Vermont. He completed a fellowship in Clinical Genetics and Dysmorphology at the University of California of San Diego, and he later joined the faculty of the University of Arizona College of Medicine in 1994. In 2003 he assumed directorship of the Cytogenetics Laboratory and received a secondary appointment in the Department of Pathology. He has been involved for many years in medical student and resident teaching, with major roles in the Medical and Molecular Genetics course and in the Integrated Problem Based Learning Course, both of which are taught to first year medical students. His major research interests are in public health genetics, in which he directs investigations of the distribution, clinical characteristics and impact of disorders such as Fetal Alcohol Syndrome, Autism Spectrum Disorders and Duchenne/Becker muscular dystrophy. He currently serves as Secretary of the American College of Medical Genetics, and from 1997-2003 was the Chairperson of the Committee on Genetics for the American Academy of Pediatrics.
Selected publications: Wang LI, Gannavarapu A, Kozinetz CA, Levy ML, Lewis R, Chintagumpala MM, Ruiz-Maldonado R, Contreras-Ruiz J, Cunniff C, Erickson RP, Lev D, Rogers M, Zackai EH, Plon S. Association of osteosarcoma with deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome. J Natl Cancer Inst 2003;95:669-674. Rice C, Doernberg N, Cunniff C, Schendel D. Public health surveillance of developmental disabilities, including the autism spectrum disorders. Am J Med Genet Part C (Semin Med Genet) 2004;125C:22-27. Meaney FJ, Miller LA, et al. A comparison of Fetal Alcohol Syndrome surveillance network and birth defect surveillance methodology in determining prevalence rates of Fetal Alcohol Syndrome. Birth Defects Research Part A 2003;1-3.
Barun De,
Ph.D., NRCC, DABCC, FACB Dr. De received his PhD degree in Biochemistry in 1979 from the University of Maryland. He had two post doctoral trainings on basic cancer research at the Cornell University and Vanderbilt University under the supervision of Dr. Leon Heppel (Member of National Academy of Science) and Dr. Stanley Cohen (Nobel Laureate, 1986) respectively. Following a faculty position at the Children Hospital of Cincinnati he underwent a fellowship on Clinical Chemistry at the University of Cincinnati Medical Center in 1992. He served as Associate Director of Clinical Chemistry at the University of Mississippi Medical Center before joining at the University of Arizona Medical Center in 2005. Presently his research interests are in cancer, diabetes and personalized medicine. Below are a few representative past publications in basic and clinical sciences. Selected publications: De BK and Kirtley ME (1977). Interaction of phosphoglycerate kinase with human erythrocyte membranes. J Biol Chem 252: 6715-6720. De BK, Misono KS, Lukas TJ, Mroczkowski B, and Cohen S (1986). A calcium- dependent 35-kilodalton substrate for epidermal growth factor receptor/kinase isolated from normal tissue. J Biol Chem 261: 13784-13792 De BK, Karr B, Ghosn S and Copeland BE (1996). Problems and practical considerations in assessing accuracy using NIST SRM 909a. Report of defective vials. Clin Chem 42: 1832-1837. Roberts WL, Safar-Pour S, De BK, Rohlfing CL, Weykamp CW and Little RL (2005). Effects of hemoglobin C and S traits on glycohemoglobin measurements by eleven methods. Clinical Chemistry 51: 776-778.
Anna R. Graham, M.D. Dr. Graham completed her Anatomic Pathology training at the U. of Arizona College of Medicine, followed by a fellowship in renal and tissue immunopathology 1977-1978, while serving as Chief Resident. Her subspecialty area is orthopedic pathology. She is one of the telepathology staff pathologists. She has also been active in organized medicine at the state and national level. She served on the Board of Directors of the American Society for Clinical Pathology for 16 years and is Past-President of that organization. Dr. Graham is very interested in medical student education and, along with many other awards, received the Basic Sciences Educator of the Year Lifetime Award in 2000.
Thomas M. Grogan, M.D. Dr. Grogan is Director of the Lymphocytic Typing Laboratory, Assistant Director of the Hematopathology Laboratory, and a member of the National Lymphoma Review Panel. After a fellowship in immunopathology and hematopathology, Dr. Grogan came to the University of Arizona to establish a Lymphocyte Typing Laboratory. The laboratory is successfully established, and affords a high level of immunotyping in lymphoma and leukemia cases. Dr. Grogan's lab also reviews a large number of hematopathology cases in consultation as a member of the National Lymphoma Review Panel.
Ray B. Nagle, M.D., Ph.D. Dr. Nagle received combined training in anatomic and clinical pathology at the University of Washington. Subsequently, he received an NIH post-doctoral fellowship in experimental pathology which led to a Ph.D. degree. He was an associate pathologist in the Department of Experimental Pathology at Walter Reed Army Institute of Research where he was involved in studies of pathogenesis of African trypanosomiasis as well as acute renal failure. Following military service, he served on the faculty at the University of Maryland where his research primarily dealt with mechanisms of acute renal failure as well as models of experimental glomerulonephritis. At the University of Arizona Health Sciences Center, he has been the medical director of electron microscopy, diagnostic immunopathology, and director of specialty laboratories. His major research interests involve studies in prostate carcinogenesis, especially factors such as cell adhesion, production of metalloproteinases, and extracellular matrix proteins. Dr. Nagle was appointed Deputy Director of the Arizona Cancer Center in January 1997. Selected publications: Nagle, RB. Role of the extracellular matrix in prostate carginogenesis. J Cell Biochem, 91:36-40, 2004 Bair EL, Chen ML, McDaniel K, Sekiguchi K, Cress AE, Nagle RB, Bowden, GT. Membrane-Type-1 Matrix Metalloprotease (MT1-MMP) Cleaves Laminin-10 and Promotes Prostate Cancer Cell Invasion. Neoplasia 2005 Apr;l7(4):380-9. Buschhorn H, Kline RR, Chamber SM, Hardy MC, Green S, Bearss D, Nagle RB. Aurora-A Over-Expression in High-Grade PIN Lesions and Prostate Cancer. Prostate 64:341-346 (2005) Calaluce R, Beck S, Bair E, Pandey R, Greer K, Hoying A, Hoying J, Mount D, Nagle R. Human Laminin-5 and Laminin-10 Mediated Gene Expression of Prostate Carcinoma Cells. The Prostate, 2005 (in press) Kremer C, Klein R, Mendelson J, Browne L, Samadzadeh L, Vanpatten K, Highstrom L, Pestano G, Nagle R. Expression of mTOR signaling pathway markers in prostate cancer progression. The Prostate, 2005 (in press)
Mark A. Nelson, Ph.D. Dr. Nelson is the associate director of research for the department of pathology. Following his Ph.D. training pharmacology/toxicology, he received an individual national research service award to pursue a postdoctoral fellowship in molecular carcinogenesis with Dr. G. Tim Bowden at the Arizona Cancer Center. Dr. Nelson has received numerous honor and awards including the Richard C. Devereaux Outstanding Young Investigator Award. His research interests involve understanding molecular mechanisms important for deregulating apoptotic signals in cancer. Dr. Nelson is also interested in the molecular and biochemical basis for the anticancer effects of selenium compounds.
Selected publications:
Dr. Ray received his M.D. degree from the University of Chicago, and did a residency in Pediatrics at the University of Washington. Following his residency and fellowship, he trained in Virology and Epidemiology at the Centers for Disease Control. His most recent appointments include IMMUNO Professor and Chair, Department of Pediatrics, Saint Louis University School of Medicine, and past President, Pan American Society for Clinical Virology. His ongoing interests are in the diagnosis, epidemiology and treatment of infectious diseases.
Lisa Rimsza, M.D. Lisa Rimsza completed her M.D. degree and Anatomic and Clinical Pathology residency training at the University of Arizona, Tucson. She then specialized in diagnostic and research Hematopathology at the University of New Mexico, Albuquerque before joining the faculty at the University of Florida, Gainesville as an attending Hematopathologist where she also directed the Molecular Diagnostics laboratory and developed research interests in mechanisms of thrombocytopenia and lymphoma. In 2002, she returned to the University of Arizona where she works as a diagnostic Hematopathologist, the Director of Flow Cytometry, and the Directory of the Molecular Genetic Pathology Fellowship. She is currently the Chairman of the Southwest Oncology Group’s Lymphoma/Myeloma Tumor Bank and Lymphoma Translational Medicine Subcommittees, working closely with the physicians at the Arizona Cancer Center in developing new treatment strategies for lymphoma. As a member of the international collaborative group, the Leukemia and Lymphoma Molecular Profiling Project, she is involved with development of new molecular methods, including gene expression profiling, for lymphoma diagnosis and prognosis. Her own research laboratory is focused on investigation of prognostic biomarkers in lymphoma and mechanisms of lost of tumor immunosurveillance. Selected publications: Rimsza L, et al. Hematgone rich proliferations can be distinguished from B-lineage acute lymphoblastic leukemia by integration of morphology, immunotype, adherin molecule expression, and architectural features. AJCP 114:66-75, 2000. Rimsza et al. Loss of MHC Class II Gene and Protein Expression in Diffuse Large B Cell Lymphoma is Related to Decreased Tumor Immunosurveillance and Poor Patient Survival Irrespective of other Prognostic Factors: A Follow-Up Study from the Leukemia and Lymphoma Molecular Profiling Project. Blood, Vol 103(11), In Press.
Kenneth J. Ryan, M.D. Dr. Ryan was the College of Medicine Dean for Academic Affairs from 2000 until his retirement in 2007. He also served as interim vice president and dean during that period. From 1972 to 2001 he was Chief of the Clinical Microbiology Laboratories and from 1990 to 2000 Medical Director of the UMC Clinical Laboratories. He trained in clinical and public health microbiology with John Sherris at the University of Washington. His publications include studies of antimicrobial susceptibility testing, bacterial identification, nosocomial infection, laboratory computer systems, and molecular epidemiology. Dr. Ryan has been a member of the American Board of Medical Microbiology, the Editorial Board of the American Journal of Clinical Pathology, the NIH Bacteriology and Mycology Study Section, the Microbiology and Parasitology Test Committee of the American Board of Pathology, and Associate Editor of Diagnostic Microbiology; and Infectious Disease. Dr. Ryan edits a textbook for medical students, Sherris Medical Microbiology, the fourth edition of which appeared in 2004.
Ziad M. Shehab, M.D. Dr. Shehab is Chief of the Section of Virology/Serology at University Medical Center. He received his pediatric training and did his chief residency in Pediatrics at the University of Virginia. He then completed his Infectious Diseases fellowship at the University of Texas at San Antonio. He came to the University of Arizona in 1983 in the department of Pediatrics where he is Head of the Section of Infectious Diseases and is Clerkship Director. He chairs the Pharmacy and Therapeutics Committee at University Medical Center. His research interests center primarily around vaccines. His other interests include medical student education, rapid viral diagnosis, coccidioidal and HIV infections in children and respiratory viral diseases.
Ronald S. Weinstein , M.D. Dr. Weinstein completed his internship and residency at Massachusetts General Hospital in Boston and was a teaching fellow at Harvard Medical School. Concurrently, he was head of the Mixter Laboratory for Electron Microscopy. From 1970-1972, he served as a major in the U.S. Air Force and was Vice Chairman of Pathology for the Aerospace Medical Research Laboratory in Ohio. He returned to Tufts for three years as an Associate Professor of Pathology. He became Chairman of the Department of Pathology at Rush-Presbyterian-St. Luke's Medical Center in Chicago, a position he held for 15 years. Dr. Weinstein then served as Head of the Department of Pathology at the University of Arizona College of Medicine from July 1990 to August 2007. Dr. Weinstein has focused his research on the composition and structure of cell membranes. Using the urinary bladder as a model system, studies have demonstrated how cellular lesions develop into malignancies. This work has instigated new methods for identifying individuals at high risk for various types of cancers. He has published more than 400 articles on topics ranging from urinary bladder cancer to informatics and telepathology. He has authored dozens of book chapters, book reviews, and editorials. Dr. Weinstein serves on the editorial boards of six major pathology journals. He was president of the United States and Canadian Academy of Pathology in 1989, the International Society of Urological Pathology in 1996, the International Council of Societies of Pathology, and the American Telemedicine Association. Dr. Weinstein is a pioneer in telepathology and serves as Director of the Arizona Telemedicine Program and the Director of T-Health Institue. Selected publications: Weinstein RS, Descour MR, Liang C, Barker G, Scott KM, Richter Ly, Krupinski EA, Bhattacharyya AK, Davis JR, Graham AR, Rennels M, Russum WC, Goodall JF, Zhou P, Olszak AG, Williams BH, Wyant JC, Bartels PH. An array microscope for ultrarapid virtual slide processing and telepathology. Design, fabrication, and validation study. Hum Pathol. 35:1303-1314, 2004. Kayser K, Szymas J, Weinstein RS. Telepathology and Telemedicine: Communication, Electronic Education and Publication in e-Health. VSV Interdisciplinary Medical Publishing, Berlin, p1-257, 2005 Kayser K, Molnar B, Weinstein RS. Digital Pathology Virtual Slide Technology in Tissue-based Diagnosis, Research and Education. VSV Interdisciplinary Medical Publishing, Berlin, p 1-193, 2006 Weinstein RS, Descour MR, Liang C, Richter L, Russum WC, Goodall JF, Zhou P, Olszak AG, Bartels PH, Reinvention of light microscopy. Array microscopy and ultrarapidly scanned virtual slides for diagnostic pathology and medical education. In: Virtual microscopy and Virtual Slides in Teaching, Diagnosis and Research, CRC Press, pp 9-35, 2005. Email: zhengw@email.arizona.edu Website: http://www.zheng.gynpath.medicine.arizona.edu/ Dr. Zheng completed his postdoctoral research fellowship at the College of Physicians and Surgeons of Columbia University, his pathology internship and residency at Cornell-New York Hospital in New York, and his gynecologic pathology including breast pathology and cytology fellowship at Women and Infants’ Hospital in Providence, Rhode Island and was a teaching fellow at Brown University. He took his first job in the University of Southern California (USC) as an Assistant Professor and attending pathologist in 1996. Concurrently, he served as an Associate Director of Molecular Pathology and Immunohistochemical laboratories. Dr. Zheng left USC for Yale University School of Medicine in 2000. He served as an Associate Professor and the Director of Gynecologic Pathology and Director of Gynecologic Pathology Fellowship at Yale for 5 years. In 2005, Dr. Zheng became a Professor of Pathology and Gynecology and the Director of Molecular Pathology at the University of Arizona. Dr. Zheng has focused his research on the precursor lesions of type II endometrial cancers, hormonal etiology of sporadic ovarian cancers, and ovarian cancer early detection. Using routine microscopy and molecular biologic methodologies, studies have demonstrated how early endometrial lesions develop into type II endometrial cancers. He is currently focusing on developing liquid-based molecular assays from endometrial samples for identifying individuals at high risk for type II endometrial cancers. In the area of sporadic ovarian cancer research, Dr. Zheng proposed a hormonal balance theory to explain how sporadic ovarian epithelial cancer develops. He has published more than 60 articles on topics ranging from gynecologic cancers and endometriosis including the earliest morphologic definition of endometriosis in the ovary. He has authored many book chapters, book reviews, and editorials. Dr. Zheng is an internationally recognized gynecologic pathologist and speaks internationally multiple times every year. Dr. Zheng was the founding president of the Association of Chinese American Physicians – California from 1998 to 2000, the secretary of the International Association of Chinese Pathologists from 2005-2006. In addition to his position at University of Arizona, Dr. Zheng is leading a major pathology program in Fudan University in China. Selected publications: Zheng W, Khurana R, Farahmand S, Wang Y, Zhang ZF, Felix JC. p53 as an significant diagnostic marker for uterine surface carcinoma--precursor lesion of uterine papillary serous carcinoma. Am J Surg Pathol 1998, 22: 1463-1473. Zheng W, Lu J, Luo F, Zheng Y, Feng Y-J, Lauchlan SC, Pike MC. Ovarian epithelial tumor growth promotion by FSH and inhibition of the effect by LH. Gynecol Oncol 2000, 76: 80-88. Zheng W, Luo F, Lu J, Baltayan A, Press M, Zhang ZF, Pike MC. Reduction of BRCA1 expression in sporadic ovarian cancer (see comment). Gynecol Oncol, 2000, 76: 294-300. Zheng W, Lu JJ, Luo F, Zhang L, Cho M, Wang CY, Stanczyk F. Tumor stroma as the main source of inhibin production in ovarian epithelial tumors. Am J Reprod Immunol, 2000, 44, 104-113. Lu JJ, Zheng Y, Kang X, Yuan J-M,. Lauchlan SC, Zheng W. Decreased luteinizing hormone receptor mRNA expression in human ovarian epithelial cancer. Gynecol Oncol, 2000, 79: 158-168. Amezcua CA, Lu JJ, Stanczyk FZ, Zheng W. Apoptosis may be an early event of Progestin Therapy for endometrial hyperplasia. Gynecol Oncol 2000, 79, 169-176. Wang J, Luo F, Chen P, Liu P, Zheng W. VEGF Expression and enhanced production by gonadotropins in ovarian epithelial tumors. Intl J Cancer 2002, 97: 163-167 Wang J, Ling-Chang L, Schwarts PE, Lauchlan SC, Zheng W. Quantitative analysis of FSHR in ovarian epithleial tumors: a novel approach to explain the field effect of ovarian cancer development in peritoneal cavity. Intl J Cancer, 2003, 103: 328-334. Wang S, Pudney J, Song J, Mor G, Schwartz PE, Zheng W. Mechanisms involved in the evolution of progestin resistance in human endometrial hyperplasia—precursor of endometrial cancer. Gynecol Oncol, 2003, 88: 108-117. Zheng W, Senturk BZ, Parkash V. Inhibin Immunohistochemical Staining: A practical approach for the surgical pathologist in the diagnosis of ovarian sex cord-stromal tumors. Adv Anat Pathol, 2003, 10: 27-38. Schwartz PE, and *Zheng W. Neoadjuvant chemotherapy for advanced ovarian cancer: the role of cytology in pretreatment diagnosis. Gynecol Oncol, 2003, 90: 644-650. Zheng W, Baker HE, Mutter GL. Involution of PTEN-Null Endometrial Glands with Progestin Therapy. Gynecol Oncol, 2004, 92: 1008-1013. Zheng W, Liang SX, Yu H, Rutherford, T, Chambers SK, Schwartz PE. Endometrial glandular dysplasia, a newly defined precursor lesion of uterine papillary serous carcinoma: a morphological study. Intl J Surg Pathol, 2004, 12: 207-223. Liang SX, Cheng L, Chambers SK, Zhou Y, Schwartz PE, Zheng W. Endometrial glandular dysplasia, a newly defined precursor lesion of uterine papillary serous carcinoma: a molecular study. Intl J Surg Pathol, 2004, 12: 319-331 Ma L, Fisk J, Crum CP, Zhang R, Ulukus EC, *Zheng W. Cervcial eosinophilic dysplasia, a newly identified variant of high-grade squamous intraepithelial neoplasia of the cervix. Am J Surg Pathol, 2004, 28: 1474-1484. Fadare O, Zheng W*. Histologic dating of the endometrium: Accuracy, reproducibility, and practical value. Adv Anat Pathol, 2005, 12 39-46. Zheng W, Schwartz PE. Serous EIC as an early form of UPSC. Recent progress of its pathogenesis and current opinions of clinical management, Gynecol Oncol, 2005, 96: 579-582. Zheng W, Li N, Wang J, Ulukus EC, Murat Ulukus M, Arici A, and Liang SX. Initial endometriosis showing direct morphologic evidence of metaplasia in the pathogenesis of ovarian endometriosis. Intl J Gynecol Pathol, 2005, 24: 164-172. Zheng W. Eosinophilic Dysplasia of the cervix, which are the invasive and cytologic counterparts? Am J Surg Pathol, 2005, 29: 837-838. Associate Professors
Margaret M. Briehl, Ph.D. Dr. Margaret Briehl received her Ph.D. in Molecular and Cellular Biology from the University of Arizona. She conducted postdoctoral research at the Arizona Cancer Center and the Swiss Institute for Experimental Cancer Research in Lausanne, Switzerland. Dr. Briehl's research laboratory is working to understand how the redox environment in lymphoma cells regulates therapy-induced apoptosis. The goal is to identify molecules involved in the mechanism of apoptosis that sense oxidative stress, but are dysfunctional in lymphoma. These would be targets for new treatment approaches. Dr. Briehl’s teaching efforts include directing a student research seminar series in the Cancer Biology Graduate Interdisciplinary Program and co-directing the Pathology 515 Basic Human Pathology Course for PhD students in the biomedical sciences. Selected publications: Butts, B.D., Tran, N.L. and Briehl, M.M. Identification of a functional peroxisome proliferator activated receptor response element in the 3' untranslated region of the human bcl-2 gene. Int. J. Oncol. 24:1305-1310, 2004. Tome, M.E., Lutz, N.W. and Briehl, M.M. Overexpression of catalase or Bcl-2 alters glucose and energy metabolism concomitant with dexamethasone resistance. Biochim. Biophys. Acta 1693:57-72, 2004. Tome, M.E., Briehl, M.M. and Lutz, N.W. Increasing the antioxidant defense in WEHI7.2 cells results in a more tumor-like metabolic profile. Int. J. Mol. Med. 15:497-501, 2005. Tome, M.E., Johnson, D.B.F., Rimsza, L.M., Roberts, R.A., Grogan, T.M., Miller, T.P., Oberley, L.W., Briehl, M.M. A redox signature score identifies diffuse large B-cell lymphoma patients with a poor prognosis. Blood 106:3594-3601, 2005. Ana Maria Lopez, M.D. Dr. Lopez is a medical oncologist who is the clinical coordinator of the clinical pathologic conferences, sponsored jointly by the Departments of Pathology and Medicine. She is also the Medical Director of the Arizona Telemedicine Program and interacts with the residents when they have research projects in telemedicine/ telepathology.
Bruce O. Parks, M.D. Dr. Parks is the Chief Medical Examiner for Pima County. He joined the faculty in 1987 after completing a fellowship in forensic pathology at the University of Arizona/Office of the Medical Examiner, Pima County. His interests include head trauma, sudden, unexpected deaths, heat stroke, and gunshot wounds. Dr. Parks is board certified in anatomic, clinical and forensic pathology.
Eric Peters, M.D. Dr. Peters is a board certified forensic pathologist and Deputy Chief Medical Examiner at the Pima County Office of the Medical Examiner. He teaches forensic pathology to the residents when they rotate to the Medical Examiner's Office and lectures both the residents and second year medical students on the same subject. He completed a fellowship in forensic pathology at Office of Chief Medical Examiner in New York, NY in June 1998 and joined the faculty shortly thereafter. His interests include sudden, unexpected natural deaths, environmental pathology, and death certification. He lectures to interested groups throughout Arizona on forensic pathology issues.
Michael W.
Riggs, D.V.M., Ph.D. After earning the D.V.M. and Ph.D. degrees, completing residency training in veterinary anatomic pathology, and an NIH postdoctoral fellowship, Dr. Riggs achieved board certification by the American College of Veterinary Pathologists (1988). He joined the Department of Comparative and Experimental Pathology at the University of Florida as Assistant Professor of Pathology and Affiliate Assistant Professor of Infectious Diseases. There he was responsible for teaching systemic pathology in the professional veterinary curriculum, directing graduate students, and training residents in veterinary anatomic pathology. His research program, initiated at the University of Florida, has focused on the immunobiology of human and bovine cryptosporidiosis. His current research is on a recombinant vaccine for bovine cryptosporidiosis; passive immunotherapy of cryptosporidiosis; and definition of the molecular pathogenesis of host cell recognition, attachment, and invasion by C. parvum. Dr. Riggs' cryptosporidiosis research is currently funded by NIH, USDA, and private industry. Research efforts have culminated in 27 refereed publications. Dr. Riggs has served as a panel member then panel chair for the USDA Competitive Grants Program, a member of an NIH NIAID AIDS - related study section, and as a reviewer for several pathology and parasitology journals. He joined the University of Arizona in 1992. Dr. Riggs teaches a general pathology course entitled, "Mechanisms of Disease" to upper division undergraduate students and graduate students and is involved in the training of residents in veterinary and comparative pathology. Selected publications: Riggs MW. 1997. Immunology: Host Response and
Development of Passive Immunotherapy and Vaccines. In Cryptosporidium and
Cryptosporidiosis. R. Fayer, Ed., CRC Press, Boca Raton, Florida, pp.
129-162. Enriquez FJ and Riggs MW. 1998. IgA Monoclonal Antibodies Against P23 in Control of Murine Cryptosporidium parvum Infection. Infection and Immunity 66:4469-4473. Riggs MW, McNeil MR, Perryman LE, Stone AL, Scherman MS, and O'Connor RM. 1999. Cryptosporidium parvum Sporozoite Pellicle Antigen Recognized by Neutralizing Monoclonal Antibody is b -Mannosylated Glycolipid. Infection and Immunity 67:1317-1322.
Ron B. Schifman, M.D. Dr. Schifman is board certified in Clinical Pathology and Medical Microbiology. He is Associate Professor at the University of Arizona and serves as chief of the Diagnostics Service Line, at the Southern Arizona VA Health Care System (SAVAHCS) which includes pathology, laboratory medicine, radiology and nuclear medicine. He is responsible for laboratory medicine training for residents at the University of Arizona College of Medicine. Dr. Schifman’s major interests are medical microbiology, quality management and medical informatics. He currently serves as acting Chief of Research at SAVAHCS. He has contributed to over 100 scientific articles, book chapters and other publications, and has been principle investigator on numerous funded research projects dealing with quality assurance, informatics and medical microbiology. Dr. Schifman has served as consultant or advisor to the Department of Health & Human Services, Centers for Disease Control, FDA, Academy of Clinical Laboratory Physicians and Scientists and National Committee for Clinical Laboratory Standards. He is past Chairman of the Council on Microbiology, American Society of Clinical Pathologists and past Vice Chairman of the College of American Pathologists Quality Practices Committee. He is also past member of the United Stated Medical Licensing Examination (USMLE) Step I Test Material Development Committee for Pathology, National Board of Medical Examiners. Catherine M. Spier, M.D. Dr. Spier is Chief of Hematology and Immunology. She has been part of the faculty since 1984, after completing a fellowship in hematopathology. Her major areas of research interest relate to the phenotypic characteristics of lymphoreticular and hematopoietic malignancies and how these may be modified as part of treatment. Other areas of interest relate to flow cytometry, as well as cell culture and cryo-preservation. Selected publications: Schnell B, Spier C. Hematopathology No. HP 98-6 (HP-32), ASCP, Hematopathology, Vol 4 (6), 1998. Galanis E, Hersh E, Stopeck A, Gonzalez R, Burch P, Spier C, Akporiaye E, Rinehart J, Edmonson J, Sobol R, Forsher C, Sondak V, Lewis B, Unger E, O'Driscoll, Selk L, Rubin J. Immunotherapy of advanced malignancy by direct gene transfer of the IL-2 DNA/DMRIE/Dope Lipid Complex: Phase I/II Experience. Journal of Clinical Oncology. In Press.
Miller T, Dahlberg S, Cassady R, Adelstein D, Spier C, Grogan T, LeBlanc M, Carlin S, Chase E, and Fisher R. Chemotherapy alone compared with chemotherapy plus radiotherapy for localized intermediate- and high-grade non-Hodgkin's lymphoma. The New England Journal of Medicine, July 1998, 339:21-26.
Davis B, Spier C, Kachin J, and Cornbleet PJ. College of American Pathologists' Reticulocyte Proficiency Testing Program using surrogate blood: Insights into contemporary clinical practice. Laboratory Hematology, 3:84-91, 1997
Assistant Professors Osama Abdelatif , MBBCh Dr. Abdelatif is a board certified cytopathologist at St. Joseph's Hospital, Tucson. He gives the residents a series of lectures in cytopathology. During an elective rotation at St. Joseph's Hospital, he trains extensively in fine needle aspiration cytology. Gail Barker, MBA, Ph.D Gail Barker, MBA, PhD is the Associate Head for the Department of Pathology and the Associate Director of Finance for the Arizona Telemedicine Program at the University of Arizona. Her PhD is in Health Administration. Prior to her coming to the University of Arizona, she was the Chief Financial Officer for the Medical School at the University of California, Irvine. She has won awards as the 1992 outstanding Health Sciences Academic Business Officer of the Year at the University of California, Irvine, and the Vision 2000 Award for the Commission on the Status of Women at University of Arizona. Most of Gail Barker's publications are in the area of Telemedicine Business. Four of her publications are listed below. Selected publications: Barker GP, Krupinski EA, Schellenberg BK, Weinstein RS: Expense comparison of a telemedicine practice versus a traditional clinical practice. Telemedicine Journal and e-Health, 10:376-379, 2004. Barker GP, McNeill KM, Krupinski, EA, Weinstein RS: The Arizona Telemedicine Program Clinical Encounters Costing for Telemedicine Services. Telemedicine Journal and e-Health, 10:403-409, 2004. Telepathology. Design, Fabrication, and Validation Study. Journal of Human Pathology, 09:1303-1314, 2004. Barker GP, Krupinski EA, Lopez AM, Tabbaa K, Hooven S, Tretschok T, Weinstein RS: Comparison of Telepain and In-Person Pain Clinic Encounters. In press. Jill Cohen, M.D.
Deborah Fuchs , M.D. Dr. Fuchs completed her anatomic and clinical pathology residency followed by a hematopathology fellowship at the University of Arizona in 2004. She is board certified in Anatomic and Clinical Pathology with subspecialty certification in Hematology. Dr. Fuchs was the first Post-Sophomore Fellow at the University of Arizona. Dr. Fuchs is currently a Clinical Assistant Professor of Pathology and, in addition to participating in the hematopathology service, she oversees point of care testing and coagulation. Dr. Fuchs plays an active role in both medical student and resident education and was awarded the John R. Davis, M.D. Outstanding Residency Teaching Award (2004-2005). Dr. Fuchs also functions as the Assistant Residency Program Director. Selected publications: Yi Z,Cohen-Barak O,Hagiwara N,Kingsley PD, Fuchs DA, Drew T. Erickson, Elliot M. Epner, James Palis, Murray H. Brilliant. Sox6 Directly Silences Epsilon Globin Expression in Definitive Erythropoiesis. PLoS Genet 2(2): e14 (2006) Cynthia M. Porterfield, D.O. Dr. Porterfield is a forensic pathologist at the Office of the Medical Examiner for Pima County. She teaches pathology residents when they rotate to the Medical Examiner's Office for their forensic pathology training and lectures to pathology residents on forensic pathology.
Anil R. Prasad, M.D. Dr. Anil Prasad completed his postgraduate training in pathology in India followed by residency training in Anatomic and Clinical Pathology at Henry Ford Hospital, Detroit, MI in 1999. He subsequently completed a fellowship in Cytopathology and was also a Fellow in Surgical Pathology at the Mayo Clinic in Rochester, MN before joining the faculty at the University of Arizona in 2001. He is also a staff pathologist at SAVAHCS, Tucson, AZ. His primary interests include Head & Neck, G.I., Prostate and Breast Pathology with particular interest in the molecular biology of cancer. He is Board Certified in Anatomic and Clinical Pathology as well as Cytopathology. He is the Clinical Director of Pathology Research & Development & Co-Director of the Molecular Pathology laboratory at the VA hospital, Tucson and has special expertise in FISH technology and Immunohistochemistry. Dr. Prasad is actively involved in research with several grants to his credit in the field of skin and prostate cancer. He is a Co-Investigator in the Colon Cancer Prevention Program of AZCC and Co- Director of the Tissue Core of the GI SPORE program of AZCC. He is also the Principal Investigator at the Tucson VA hospital for a large National VA biorepository grant.
Margaret A. Rennels, M.D. Dr. Rennels completed her anatomic and clinical pathology residency followed by an immunopathology fellowship at the University of Arizona in 1988. She worked in both large reference laboratories and busy community hospital private practice settings. Dr. Rennels joined the Southern Arizona VA Health Care System (SAVAHCS) as a Staff Pathologist in 1997 and now enjoys teaching anatomic pathology to residents and medical students at University Medical Center. Her areas of subspecialty interest are ophthalmic pathology and cytopathology. Selected publications: Lippmann SM, Buzaid AC, Steinbronn DV, Stanisic TH, Rennels MA, Yang PJ, Garewal HS, Ahmann FR. Cranial Metastases from Prostate Cancer Stimulating Meningioma; Report of Two Cases and Review of the Literature. Neurosurgery 19:820-823, 1986. Fuchs ME, Brawer MK, Rennels MA, Nagle RB. The Relationship of Basement Membrane to Histologic Grade of Human Prostate Carcinoma. Modern Pathology, 2:105-111, 1989. Brawer MK, Rennels MA, Nagle RB, Schifman RB, Gaines J.
Serum PSA in Men Undergoing Simple Prostatectomy. Am J Clin. Dr. Scott has been in the Department of Pathology at the Arizona Health Sciences Center and University Phyisicians Healthcare Hospital, Kino Campus in Tucson Arizona after her completing her anatomic and clinical pathology residency followed by an Immunopathology and Renal fellowship at the University of Arizona. She is the Medical Director of the University Medical Center Pathology Laboratories as well as the UPHK Pathology Laboratory. She is active in the Arizona Telemedicine Program, in which she is the Assistant Medical Director. Her research interests and projects include pathology in Telemedicine, prostate neoplasia, prognostic tumor markers, renal ultrastructure and transplantation pathology.
Dr. Tome received her Ph.D. from the Department of
Biochemistry at the University of Arizona in 1996. Her dissertation
dealt with understanding the role of ornithine decarboxylase regulation in
cellular metabolism. The normal tight regulation of this enzyme both
prevents uncontrolled growth and prevents apoptosis. From these
studies she became interested in the regulation of apoptotic pathways in Selected publications: Tome ME, Baker AF, Powis G, Payne CM and Briehl MM 2001. Catalase-overexpressing thymocytes are resistant to glucocorticoid-induced apoptosis and exhibit net tumor growth. Cancer Res. 61:2766-2773. Tome ME, and Briehl MM. 2001. Thymocytes selected
for resistance to hydrogen peroxide show altered antioxidant enzyme Lutz NW, Tome ME, Aiken NR and Briehl MM, 2002. Changes in phosphate metabolism in thymoma cells suggest mechanisms for resistance to dexamethasone-induced apoptosis. A31P NMR spectroscopic study of cell extracts. NMR Biomed. 15:356-366.
Dr. David Winston graduated from the Medical University of South Carolina and completed his Anatomic and Clinical Pathology residency at the University of Virginia Health Sciences Center in Charlottesville, VA. He traveled to Albuquerque, NM where he did a forensic pathology fellowship at the Office of the Medical Investigator through the University of New Mexico Health Sciences Center. He then traveled back across the country where he was an Assistant Professor of Pathology at Wake Forest University School of Medicine in Winston-Salem, NC for 4.5 years. One more trip back across the country in January 2003 brought him to the Forensic Science Center in Tucson where his duties have included teaching pathology residents and medical students about forensic pathology. Other than spending time with his family, Dr. Winston can be found at a driving range, golf course or the Arizona Sonoran Desert Museum.
Dr. Wolk is the director of the Molecular Diagnostics and Translational Research Core Laboratories at the Southern Arizona VA Health Care System and is co-director of the Molecular Genetics Pathology fellowship. She joined the faculty in 2001 after completing her post-doctoral microbiology fellowship and molecular diagnostic training at Mayo Clinic in Rochester, MN. Dr. Wolk received her master's degree in health administration from Wilkes University and her B.S. degree in microbiology from Penn State University. She is board-certified as a medical technologist, a specialist in clinical and public health Microbiology, and a diplomat of the American Board of Medical Microbiology. Her national service activities include her positions as a Waksman lecturer for the American Society of Microbiology, an editor for the Journal of Clinical Microbiology, and a subcommittee member of the National Committee for Clinical Laboratory Standards. Dr. Wolk is the recipient of several national scientific merit awards for translational research. Her research focuses on molecular diagnosis, epidemiology, and pathogenesis of infectious disease, as well as the microbiological aspects of water quality and infectious public health threats. Her laboratory is recognized as a model for quality practices in molecular diagnostic microbiology and complies with Good Laboratory Practice (GLP) regulations. The American Water Works Research Foundation and the USEPA currently support her research. Some recent publications include: Selected publications: Hayden RT, Isotalo PA, Parrett T, Wolk DM, Qian X, Roberts GD, Lloyd RV. Diagn Mol Pathol. 2003 In situ hybridization for the differentiation of Aspergillus, Fusarium, and Pseudallescheria species in tissue section.Mar;12(1):21-6. Wolk, D.M., Sloan, L.M., Schneider, S.K., and Rosenblatt, J.E. Real-time PCR method for detection of Encephalitozoon intestinalis from stool specimens. J Clin Microbiol. 2002 Nov;40(11):3922-8. Baghai, M., Osmon, D.R., Wolk, D.M., Wold, L.E., Haidukewich, G.J. and Matteson, E.L. 2001. Fatal sepsis in a patient with rheumatoid arthritis treated with etancercept. Mayo Proceedings. 76:653-656. Wolk, D.M., Johnson, C.H., Rice, E.W., Marshall, M.M., Grahn, K.F., Plummer, C.B., and C.R. Sterling. 2000. A spore counting method and cell culture model for chlorine disinfection studies of Encephalitozoon syn. Septata intestinalis. Appl.Environ.Microbiol. 66(4) 1266-1273. Wolk, D. M. and D. H. Persing. 2002.
Clinical Microbiology: Looking Ahead, p. 429-450.
In
A. L. Truant (ed.), Commercial Methods in Clinical Microbiology. ASM Press,
Washington,D.C.
Wolk, D., S. Mitchell, and R. Patel.
2001. Principles of molecular microbiology testing methods.
Infect.Dis.Clin.North Am. 15:1157-1204.
Professors Emeritus
John R. Davis, M.D. Dr. Davis served as Chief of Anatomic Pathology, Director of Surgical Pathology, and Medical Director of Cytogenetics. Areas of special interests to Dr. Davis included gynecologic pathology, cytology, and cytogenetics. He was involved in flow cytometry (DNA tumor ploidy), human papilloma virus research, and interphase cytogenetics (DNA in situ hybridization). He served as the institutional pathologist for two national research and service organizations: The Gynecology Oncology Group and the Pediatric Oncology Group.
Dr. Huestis did postgraduate training in pathology and related fields in Canada, Sweden, England and the U.S.A. He began concentrating on the field of blood transfusion and immunohematology in Chicago in 1960, working on erythrocyte antigens and antibodies and their relationship to difficulties and complications of blood transfusion, and on the development of frozen blood systems. At the University of Arizona since 1969, he has developed technical procedures with blood cell separators for the collection of white blood cells and platelets for transfusion, the treatment of leukemic patients with dangerous excesses of white blood cells or platelets, and the rapidly developing fields of plasma exchange and histocompatibility. Dr. Huestis has served as a director and vice president of the American Association of Blood Banks, and on many of its committees; was editor of two editions of its Technical Manual, and received its John Elliott award. He was an associate editor of the journal Transfusion, 1968-95. He served on several advisory committees for the National Institutes of Health; has been a consultant to the U.S. Army and Air Force, and took part in two scientific exchange visits to the Soviet Union under the Soviet-American Health Exchange. He considers one of his most important achievements to have been the textbook Practical Blood Transfusion, co-authored with Joseph R. Bove and John Case, published by Little, Brown and Co., the 4th edition of which appeared in 1988. Dr. Huestis is now in retirement. He works as a writer from his home. Selected publications: Huestis DW, Bove JR, and Case J: Practical Blood Transfusion, 4th ed., Boston: Little Brown, 1988. Bogdanov AA. The Struggle for Viability. Translated from the Russian & edited by Douglas W. Huestis. Philadelphia: Xlibris, 2001 Huestis DW, Glasser L. The neutrophil in transfusion medicine. Transfusion 1994;34:630-646 Huestis, Douglas W. Russia's National Research Center for Hematology: Its role in the development of blood banking, Transfusion 2002;42:490-4.
Samuel H. Paplanus , M.D. Dr. Paplanus earned his BA and MD degrees at Vanderbilt University. He then completed a Pathology residency at Vanderbilt University Hospital. He served 2 years in the United States Army at the Chemical Warfare Laboratories. This was followed by a fellowship in Internal Medicine at Yale and a fellowship in Pathology at Johns Hopkins. Dr. Paplanus then spent 10 years in the Pathology Department at the Johns Hopkins Medical School and on the Medical Staff of the Johns Hopkins Hospital. In 1972 he came to the Pathology Department at the University of Arizona Medical School as a general surgical pathologist. His special interest was the development of computer-based information systems in Pathology. Dr. Paplanus served actively in the United and Canadian Academy of Pathology, in the American Society for Clinical Pathology, and in the Arthur Purdy Stout Society of Surgical Pathologists. In 1990 he retired with the title of Professor Emeritus of Pathology. Since retirement he has maintained his interest in computer-based database management and has been active in the Pima County Medical Society.
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Douglas W. Huestis, M.D. 